Article

The genetics of human C-reactive protein and complement C3 expression in health and disease

2010-01-01

Abstract excerpt

C-reactive protein (CRP) and complement component C3 are both plasma proteins involved in antigen recognition by the innate immune system. They may play a role in the pathogenesis of immune-mediated diseases including systemic lupus erythematosus (SLE) and coronary heart disease. CRP is heritable, but there is uncertainty over the key genetic variants influencing expression. C3 heritability has not been demonstrat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e30a435a-738d-51b2-a626-46e3281c5795
DOI: 10.25560/5535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The genetics of human C-reactive protein and complement C3 expression in health and diseaseDOI 10.25560/5535Read

The heritability and genetics of complement C3 expression in UK SLE families.Semantic proximity Read

Medical Records-Based Genetic Studies of the Complement System.Semantic proximity Read

Genetic analysis of over half a million people characterises C-reactive protein loci.Semantic proximity Read

Genetic determinants of C-reactive protein.Semantic proximity Read

The genetic and phenotypic correlates of neonatal Complement Component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disordersSemantic proximity Read

Polymorphism of the complement components in human pathology.Semantic proximity Read

C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysisSemantic proximity Read

Genetic variants in complement-related genes: potential implications for cancer risk and progressionSemantic proximity Read

Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.Semantic proximity Read

Genetic variability shapes the alternative pathway complement activity and predisposition to complement-related diseases.Semantic proximity Read

The complotype: dictating risk for inflammation and infection.Semantic proximity Read

Complement genetics and susceptibility to inflammatory disease. Lessons from genotype-phenotype correlations.Semantic proximity Read