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Article

The complotype: dictating risk for inflammation and infection.

Trends in immunology - 1 Oct 2012

Harris Claire L, Heurich Meike, Rodriguez de Cordoba Santiago, Morgan B Paul

Abstract excerpt

Complement is a key component of immune defence against infection; it potently drives inflammation at sites of pathology and is essential for killing of pathogens. Genetic linkage of common complement polymorphisms to disease has advanced the concept that subtle changes in complement activity significantly affect disease risk. Functional analyses of disease-linked polymorphic variants demonstrate that, although...

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Identifiers

PMID: 22749446
DOI: 10.1016/j.it.2012.06.001
PMCID: PMC3460238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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