Polymorphism of the complement components in human pathology.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Polymorphism of the complement components in human pathology.

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna - 1 Jan 2000

Brai M, Accardo P, Bellavia D

Abstract excerpt

The complement system is an important part of non clonal or innate immunity that collaborates with acquired immunity to kill pathogens and to facilitate the clearance of immune complexes. The complement is made up of 20 distinct plasma proteins and 9 different membrane proteins. Three components, factor B, C2 and C4 (with 2 isotypes), are coded by polymorphic HLA-linked genes and are sometimes referred to as...

Topics

Adrenal Hyperplasia, Congenital
Aged
Aged, 80 and over
Alleles
Child
Complement C2
Complement C3
Complement C4
Complement System Proteins
Diabetes Mellitus, Type 1
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Linkage

Genetic Markers

Humans

IgA Deficiency

IgG Deficiency

Lupus Erythematosus, Systemic

Major Histocompatibility Complex

Source

Open in PubMed

Identifiers

PMID: 7946894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7946894-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism of the complement components in human pathology.PMID 7946894Read ↗

Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases.Semantic proximity Read ↗

Complement genetics, deficiencies, and disease associationsSemantic proximity Read ↗

Common and rare genetic variants of complement components in human disease.Semantic proximity Read ↗

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune DiseasesSemantic proximity Read ↗

Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.Semantic proximity Read ↗

Complement regulators in human disease: lessons from modern genetics.Semantic proximity Read ↗

Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement DeficienciesSemantic proximity Read ↗

Complement C3 and its polymorphism: biological and clinical consequences.Semantic proximity Read ↗

Complement in human diseases: Lessons from complement deficiencies.Semantic proximity Read ↗

Complement dysregulation and disease: from genes and proteins to diagnostics and drugs.Semantic proximity Read ↗

Complement Dysregulation and Disease: Insights from Contemporary Genetics.Semantic proximity Read ↗

Genetic variability shapes the alternative pathway complement activity and predisposition to complement-related diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.