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Article

Genetic analysis of over half a million people characterises C-reactive protein loci.

Nature communications - 22 Apr 2022

Said Saredo, Pazoki Raha, Karhunen Ville, Võsa Urmo, Ligthart Symen, Bodinier Barbara, Koskeridis Fotios, Welsh Paul, Alizadeh Behrooz Z, Chasman Daniel I, Sattar Naveed, Chadeau-Hyam Marc, Evangelou Evangelos, Jarvelin Marjo-Riitta, Elliott Paul, Tzoulaki Ioanna, Dehghan Abbas

Abstract excerpt

Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Biobank participants (N = 427,367, European descent) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (total N = 575,531 European descent). We identify 266 independent...

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C-Reactive Protein
Genetic Associations and Epidemiology
Genetic Loci
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 35459240
DOI: 10.1038/s41467-022-29650-5
PMCID: PMC9033829

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