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Article

Medical Records-Based Genetic Studies of the Complement System.

Journal of the American Society of Nephrology : JASN - 1 Aug 2021

Khan Atlas, Shang Ning, Petukhova Lynn, Zhang Jun, Shen Yufeng, Hebbring Scott J, Moncrieffe Halima, Kottyan Leah C, Namjou-Khales Bahram, Knevel Rachel, Raychaudhuri Soumya, Karlson Elizabeth W, Harley John B, Stanaway Ian B, Crosslin David, Denny Joshua C, Elkind Mitchell S V, Gharavi Ali G, Hripcsak George, Weng Chunhua, Kiryluk Krzysztof

Abstract excerpt

BACKGROUND: Genetic variants in complement genes have been associated with a wide range of human disease states, but well-powered genetic association studies of complement activation have not been performed in large multiethnic cohorts. METHODS: We performed medical records-based genome-wide and phenome-wide association studies for plasma C3 and C4 levels among participants of the Electronic Medical Records and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33941608
DOI: 10.1681/ASN.2020091371
PMCID: PMC8455263

Genes

C3
C4A
C4B
CFH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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