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Article

Low dose of a non-urea selective GIRK channel activator improves hippocampal-dependent synaptic plasticity and memory disrupted by amyloid-β oligomers

2024-11-05

Abstract excerpt

Increased neural activity characterizes early Alzheimer’s disease (AD), serving as a prognostic indicator for disease progression and cognitive decline. Mechanisms that drive this hyperactivity and their behavioral effects remain mostly unrevealed, although normalizing altered excitability levels has been shown to reverse cognitive impairment in early AD, both in animals and humans. Soluble amyloid- β oligomers (...

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Literature Corpus work
e2fa1c2a-fda1-5c61-94cd-3c890984689d
DOI
10.1101/2024.11.05.622060
Open publication

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Low dose of a non-urea selective GIRK channel activator improves hippocampal-dependent synaptic plasticity and memory disrupted by amyloid-β oligomersDOI 10.1101/2024.11.05.622060
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