Implications of Oligomeric Amyloid-Beta (oAβ42) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline.

doi:10.1523/JNEUROSCI.0876-20.2020

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Implications of Oligomeric Amyloid-Beta (oAβ42) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jan 2021

George Andrew A, Vieira Jaime M, Xavier-Jackson Cameron, Gee Michael T, Cirrito John R, Bimonte-Nelson Heather A, Picciotto Marina R, Lukas Ronald J, Whiteaker Paul

Abstract excerpt

Neuronal and network-level hyperexcitability is commonly associated with increased levels of amyloid-β (Aβ) and contribute to cognitive deficits associated with Alzheimer's disease (AD). However, the mechanistic complexity underlying the selective loss of basal forebrain cholinergic neurons (BFCNs), a well-recognized characteristic of AD, remains poorly understood. In this study, we tested the hypothesis that the...

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PMID: 33239400
DOI: 10.1523/JNEUROSCI.0876-20.2020
PMCID: PMC7821864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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