Article
Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.
Molecular brain - 25 May 2013
Maurin Hervé, Lechat Benoit, Dewachter Ilse, Ris Laurence, Louis Justin V, Borghgraef Peter, Devijver Herman, Jaworski Tomasz, Van Leuven Fred
Abstract excerpt
BACKGROUND: GSK3β is involved in a wide range of physiological functions, and is presumed to act in the pathogenesis of neurological diseases, from bipolar disorder to Alzheimer's disease (AD). In contrast, the GSK3α isozyme remained largely ignored with respect to both aspects. RESULTS: We generated and characterized two mouse strains with neuron-specific or with total GSK3α deficiency. Behavioral and...
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