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Article

Tissue-specific Mitotic Clocks Link Cumulative Stem Cell Divisions to Human Cancer Susceptibility

2026-03-09

Abstract excerpt

<title>Abstract</title> <p>Why cancer risk varies so dramatically across human tissues remains a fundamental question in oncology. While this variation has been linked to differences in total stem cell divisions (TNSD), molecular tools for measuring tissue-specific proliferative history are lacking. Existing DNA methylation-based mitotic clocks conflate chronological aging with mitotic activity and apply pan-tiss...

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Literature Corpus work
e2edfae3-1075-56a2-ac8c-f77db044ffd2
DOI
10.21203/rs.3.rs-9013656/v1
Open publication

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Tissue-specific Mitotic Clocks Link Cumulative Stem Cell Divisions to Human Cancer SusceptibilityDOI 10.21203/rs.3.rs-9013656/v1
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