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An improved epigenetic counter to track mitotic age in normal and precancerous tissues

2023-07-29

Abstract excerpt

The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) clocks are promising tools to molecularly track mitotic age, yet their relationship is underexplored and their potential for cancer risk prediction in normal tissues remains to be demonstrated. Here we build and validate an improved pan-t...

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Identifiers and source

Literature Corpus work
68ed9ce6-7fa1-59cb-b045-7baf4dc20c09
DOI
10.1101/2023.07.27.549809
Open publication

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An improved epigenetic counter to track mitotic age in normal and precancerous tissuesDOI 10.1101/2023.07.27.549809
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