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Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer

2 Apr 2025

Abstract excerpt

BACKGROUND: Aging is a key risk factor for many diseases, including cancer, and a better understanding of its underlying molecular mechanisms may help to prevent, delay, or treat age-related pathologies. Epigenetic alterations such as DNA methylation (DNAme) changes are a hallmark of aging and form the basis of so-called epigenetic clocks, yet their functional relevance and directionality in different organs...

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PMID: 40175686
DOI: 10.1038/s43856-025-00739-4

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