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Article

An improved epigenetic counter to track mitotic age in normal and precancerous tissues.

Nature communications - 17 May 2024

Zhu Tianyu, Tong Huige, Du Zhaozhen, Beck Stephan, Teschendorff Andrew E

Abstract excerpt

The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) clocks are promising tools to molecularly track mitotic age, yet their relationship is underexplored and their potential for cancer risk prediction in normal tissues remains to be demonstrated. Here we build and validate an improved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38760334
DOI: 10.1038/s41467-024-48649-8
PMCID: PMC11101651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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