Article
Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.
Science (New York, N.Y.) - 2 Jan 2015
Tomasetti Cristian, Vogelstein Bert
Abstract excerpt
Some tissue types give rise to human cancers millions of times more often than other tissue types. Although this has been recognized for more than a century, it has never been explained. Here, we show that the lifetime risk of cancers of many different types is strongly correlated (0.81) with the total number of divisions of the normal self-renewing cells maintaining that tissue's homeostasis. These results...
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