Article

Replicative history as a major determinant of epigenetic noise across human tissues

2026-08-24

Abstract excerpt

DNA methylation changes accumulate with age through both regulated and stochastic processes, yet the determinants of epigenetic information loss remain poorly defined. Using genome-wide DNA methylation profiles from 1,531 healthy human samples spanning 14 tissues, we quantified epigenetic noise by Shannon entropy and corrected it for cellular and tissue heterogeneity. Adjusted entropy was consistently low in promo...

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Literature Corpus work: 622daaa9-4c6d-5bee-aa3b-9d0c737df61d
DOI: 10.64898/2026.08.19.745715

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