Article

MicroRNA-155 regulates osteogenesis and bone mass phenotype via targeting S1PR1 gene

2022-02-19

Abstract excerpt

MicroRNA-155 (miR155) is overexpressed in various inflammatory diseases and cancer, in which bone resorption and osteolysis are frequently observed. However, the role of miR155 on osteogenesis and bone mass phenotype is still unknown. Here, we report a low bone mass phenotype in the long bone of miR155-Tg mice compared with control mice. In contrast, miR155-KO mice showed a high bone mass phenotype. miR155-KO mice...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2ea5d66-b7c7-55d5-b57f-f2655a453898
DOI: 10.1101/2022.02.18.480982

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-155 regulates osteogenesis and bone mass phenotype via targeting S1PR1 geneDOI 10.1101/2022.02.18.480982Read

Mir155 regulates osteogenesis and bone mass phenotype via targeting S1pr1 geneSemantic proximity Read

The regulatory effect of miR-181c-5p on the differentiation function of bone marrow mesenchymal stem cells in postmenopausal osteoporotic miceSemantic proximity Read

Osteoclast signaling-targeting miR-146a-3p and miR-155-5p are downregulated in Paget's disease of boneSemantic proximity Read

miR-324 mediates bone homeostasis through the regulation of osteoblast and osteoclast differentiation and activitySemantic proximity Read

The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation.Semantic proximity Read

MicroRNA-155 facilitates skeletal muscle regeneration by balancing pro- and anti-inflammatory macrophages.Semantic proximity Read

A NOTCH1/LSD1/BMP2 Co-Regulatory Network Mediated by miR-137 Negatively Regulates Osteogenesis of Human Adipose-Derived Stem CellsSemantic proximity Read

miR-324 mediates bone homeostasis through the regulation of osteoblast and osteoclast differentiation and activitySemantic proximity Read

The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration.Semantic proximity Read

lncRNA SNHG1 attenuates osteogenic differentiation via the miR‑101/DKK1 axis in bone marrow mesenchymal stem cells.Semantic proximity Read

MicroRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signalingSemantic proximity Read

Reduced femoral bone mass in both diet-induced and genetic hyperlipidemia mice.Semantic proximity Read