Article
The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation.
Bone - 1 Oct 2024
Wang Xueting, Zhang Hui, Hu Ling, He Jin, Jiang Qifeng, Ren Lingfei, Yu Ke, Fu Mengdie, Li Zhikun, He Zhixu, Zhu Junhao, Wang Ying, Jiang Zhiwei, Yang Guoli
Abstract excerpt
Gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) can cause high-bone-mass (HBM) phenotype, with 19 identified mutations so far. The A242T mutation in LRP5 has been found in 9 families, making it one of the most prevalent mutations. However, the correlation between the A242T mutation and HBM phenotype remains unverified in animal models. This study aimed to investigate...
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