Article
The ALT pathway generates telomere fusions that can be detected in the blood of cancer patients
2022-01-28
Abstract excerpt
Telomere fusions (TFs) can trigger the accumulation of diverse genomic rearrangements and the acquisition of oncogenic alterations leading to malignant transformation and resistance to chemotherapy. Despite their relevance in tumour evolution, our understanding of the patterns and consequences of TFs in human cancer remains limited. Here, we have characterized the rates and spectrum of somatic TFs across >30 cance...
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Identifiers and source
- Literature Corpus work
- e2d828cf-d3f9-5c60-a8f2-b397cde94f87
- DOI
- 10.1101/2022.01.25.477771