Article
Genomic evolution and chemoresistance in germ-cell tumours.
Nature - 30 Nov 2016
Taylor-Weiner Amaro, Zack Travis, O'Donnell Elizabeth, Guerriero Jennifer L, Bernard Brandon, Reddy Anita, Han G Celine, AlDubayan Saud, Amin-Mansour Ali, Schumacher Steven E, Litchfield Kevin, Turnbull Clare, Gabriel Stacey, Beroukhim Rameen, Getz Gad, Carter Scott L, Hirsch Michelle S, Letai Anthony, Sweeney Christopher, Van Allen Eliezer M
Abstract excerpt
Germ-cell tumours (GCTs) are derived from germ cells and occur most frequently in the testes. GCTs are histologically heterogeneous and distinctly curable with chemotherapy. Gains of chromosome arm 12p and aneuploidy are nearly universal in GCTs, but specific somatic genomic features driving tumour initiation, chemosensitivity and progression are incompletely characterized. Here, using clinical whole-exome and...
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