Article
TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes.
Genes - 21 Jul 2020
Armendáriz-Castillo Isaac, López-Cortés Andrés, García-Cárdenas Jennyfer, Guevara-Ramírez Patricia, Leone Paola E, Pérez-Villa Andy, Yumiceba Verónica, Zambrano Ana K, Guerrero Santiago, Paz-Y-Miño César
Abstract excerpt
Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85-90% reactivate telomerase, while 10-15% use the alternative lengthening of telomeres (ALT). Due to anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism to ALT; in fact, the co-existence between both mechanisms has been observed in some cancers. Although different elements in the ALT pathway...
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