Article
Telomere sequence content can be used to determine ALT activity in tumours.
Nucleic acids research - 1 Jun 2018
Lee Michael, Teber Erdahl T, Holmes Oliver, Nones Katia, Patch Ann-Marie, Dagg Rebecca A, Lau Loretta M S, Lee Joyce H, Napier Christine E, Arthur Jonathan W, Grimmond Sean M, Hayward Nicholas K, Johansson Peter A, Mann Graham J, Scolyer Richard A, Wilmott James S, Reddel Roger R, Pearson John V, Waddell Nicola, Pickett Hilda A
Abstract excerpt
The replicative immortality of human cancer cells is achieved by activation of a telomere maintenance mechanism (TMM). To achieve this, cancer cells utilise either the enzyme telomerase, or the Alternative Lengthening of Telomeres (ALT) pathway. These distinct molecular pathways are incompletely understood with respect to activation and propagation, as well as their associations with clinical outcomes. We have...
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