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The ALT pathway generates telomere fusions that can be detected in the blood of cancer patients

2 Jan 2024

Abstract excerpt

Telomere fusions (TFs) can trigger the accumulation of oncogenic alterations leading to malignant transformation and drug resistance. Despite their relevance in tumour evolution, our understanding of the patterns and consequences of TFs in human cancers remains limited. Here, we characterize the rates and spectrum of somatic TFs across >30 cancer types using whole-genome sequencing data. TFs are pervasive in...

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PMID: 38167290
DOI: 10.1038/s41467-023-44287-8

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