Tumoral glucocorticoids induce a phagocytic CD68+/CD163+/C1Q+ macrophage phenotype primed for IFNγ-driven CXCL9 secretion

Abstract excerpt

<title>Abstract</title> <p>Glucocorticoids (GCs) play a multifaceted role in modulating immune responses in cancer. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy that produces excessive glucocorticoids in ~ 60%, providing a unique model to study intra-tumoral GC activity. Here, we report that ACC tumors are strongly infiltrated by CD68+/CD163+ 'M2-like' macrophages, independent of cortisol overpro...

Topics

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• Adrenal Cortex Neoplasms
• Antigens, Differentiation, Myelomonocytic
• Glucocorticoids
• Immune Checkpoint Inhibitors
• Interferon-gamma
• Mifepristone
• Phagocytosis
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

e2c1f115-a818-5330-b4df-8a15148c439e

DOI

10.21203/rs.3.rs-6213228/v1