Article

CAR T cells and T cells phenotype and function are impacted by glucocorticoid exposure with different amplitude.

2023-10-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background. </bold> Chimeric antigen receptor (CAR) T cell therapy is associated with high risk of adverse events. Glucocorticoids (GCs) are cornerstone in the management of high-grade cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Given the potentially deleterious effects of GCs on CAR T cells anti-tumor activity, increasing ou...

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Literature Corpus work: a7f6f051-277e-59f5-8c22-0e7ca32ad65a
DOI: 10.21203/rs.3.rs-3366592/v1

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