Autocrine signaling in hormonally active cancer induces antigen expression for immunotherapy

Abstract excerpt

Endocrine, but also many non-endocrine cancers produce hormones that modulate immune-recognition and -therapy. We used adrenocortical carcinoma (ACC) as model that produces high amounts of glucocorticoids (GCs) and studied cancer antigen expression and recognition. Our study revealed that the oncofetal antigen ROR1 is induced by autocrine GC-signaling and that its transcription is regulated by GC-activated human g...

Topics

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• Adrenal and Paraganglionic Tumors
• Adrenal Cortex Neoplasms
• Antineoplastic Agents, Hormonal
• Cancer, Hypoxia, and Metabolism
• Combined Modality Therapy
• Diagnosis, Differential
• Diagnostic Imaging
• Genetic Predisposition to Disease

Identifiers and source

Literature Corpus work

22afcfe2-1b07-550b-a012-6c55b9d9e396

DOI

10.1101/2025.01.28.632923