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Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy

2021-08-20

Abstract excerpt

<h4>Summary</h4> Cystatin C (CyC) is a secreted cysteine protease inhibitor and its biological functions remain insufficiently characterized. Plasma CyC is elevated in many patients, especially when receiving glucocorticoid (GC) treatment. Endogenous GCs are essential for life and are appropriately upregulated in response to systemic stress. Here we empirically connect GCs with systemic regulation of CyC. We used...

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Literature Corpus work
cea3f807-b11c-5038-ad9f-61f660f7a0ed
DOI
10.1101/2021.08.17.21261668
Open publication

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Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapyDOI 10.1101/2021.08.17.21261668
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