Back to search

Article

Multiplatform Integrative Analyses of Immunosuppressive Signatures in Cortisol-secreting Adrenocortical Carcinoma

2021-01-16

Abstract excerpt

Adrenocortical carcinoma (ACC) is a rare but highly aggressive malignancy and nearly half of ACC tumors have been shown to overproduce and secrete adrenal steroids. Excess cortisol secretion, in particular, has been associated with poor prognosis among ACC patients. Furthermore, recent immunotherapy clinical trials demonstrated significant immunoresistance among cortisol-secreting ACC (CS-ACC) patients when compar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
178f596d-27b4-5181-9418-7b8f6dd978d0
DOI
10.1101/2021.01.14.426712
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Multiplatform Integrative Analyses of Immunosuppressive Signatures in Cortisol-secreting Adrenocortical CarcinomaDOI 10.1101/2021.01.14.426712
The Steroidal Profile Modulates Adaptive Immune Response and Prognosis in Adrenocortical Carcinoma: Analysis of TCR and BCR Repertoires.Semantic proximity
Adrenocortical Carcinoma Steroid Profiles: In Silico Pan-Cancer Analysis of TCGA Data Uncovers Immunotherapy Targets for Potential Improved OutcomesSemantic proximity
Multiplatform Computational Analysis of Mast Cells in Adrenocortical Carcinoma Tumor MicroenvironmentSemantic proximity
Molecular subtyping of adrenocortical carcinoma reveals distinct subtypes with prognostic and therapeutic implications.Semantic proximity
Glucocorticoids induce a phagocytic C1Q+ macrophage phenotype primed for IFNγ-dependent CXCL9 secretion.Semantic proximity
Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging TherapiesSemantic proximity
Molecular Cluster Mining of Adrenocortical Carcinoma via Multi-Omics Data Analysis Aids Precise Clinical TherapySemantic proximity
Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma.Semantic proximity
Establishment of a patient-derived adrenocortical carcinoma 3D tumor construct platform for evaluation of therapeutic strategiesSemantic proximity
The Characteristics of Tumor Microenvironment Predict Survival and Response to Immunotherapy in Adrenocortical CarcinomasSemantic proximity
Autocrine signaling in hormonally active cancer induces antigen expression for immunotherapySemantic proximity
Adrenocortical cancer.Semantic proximity
Select a neighboring publication to make it the new centre.