Article

Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability

2024-04-10

Abstract excerpt

<h4>ABSTRACT</h4> UTRs contain crucial regulatory elements for RNA stability, translation and localization, so their integrity is indispensable for gene expression. Approximately 3.7% of genetic variants associated with diseases occur in UTRs, yet a comprehensive understanding of UTR variant functions remains limited due to inefficient experimental and computational assessment methods. To systematically evaluate...

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Literature Corpus work: e2a54f21-3f7a-5db9-9c05-1ceef491d7b7
DOI: 10.1101/2024.04.10.588845

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