Article

Integrative analysis reveals RNA G-Quadruplexes in UTRs are selectively constrained and enriched for functional associations

2019-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Identifying regulatory elements in the noncoding genome is a fundamental challenge in biology. G-quadruplex (G4) sequences are abundant in untranslated regions (UTRs) of human messenger RNAs, but their functional importance remains unclear. By integrating multiple sources of genetic and genomic data, we show that putative G-quadruplex forming sequences (pG4) in 5’ and 3’ UTRs are selectively con...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1da4ced7-1cd9-527a-ad77-737931574a1e
DOI: 10.1101/666842

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative analysis reveals RNA G-Quadruplexes in UTRs are selectively constrained and enriched for functional associationsDOI 10.1101/666842Read

Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations.Semantic proximity Read

The Impact of Non-coding G-quadruplex Variants on Human Traits and Disease SusceptibilitySemantic proximity Read

G4mer: An RNA language model for transcriptome-wide identification of G-quadruplexes and disease variants from population-scale genetic dataSemantic proximity Read

G-quadruplex structural variations in human genome associated with single-nucleotide variations and their impact on gene activity.Semantic proximity Read

Regulatory features aid interpretation of 3’UTR VariantsSemantic proximity Read

A Mammalian Genomic Signature Shaped by Single Nucleotide Variants Regulates Transcriptome Integrity and DiversitySemantic proximity Read

A systematic delineation of 3′UTR regulatory elements and their contextual associationsSemantic proximity Read

Variation and selection at predicted G-quadruplexes across the human pangenomeSemantic proximity Read

Analysis of nucleotide variations in human g-quadruplex forming regions associated with disease statesSemantic proximity Read

A mammalian genomic signature shaped by single nucleotide variants regulates transcriptome integrity and diversity.Semantic proximity Read

The Functional Map of Ultraconserved Regions in Humans, Mice and RatsSemantic proximity Read

Genetic variations in G-quadruplex forming sequences affect the transcription of human disease-related genes.Semantic proximity Read