Article

Genome-wide functional screen of 3’UTR variants uncovers causal variants for human disease and evolution

2021-01-13

Abstract excerpt

3’ untranslated region (3’UTR) variants are strongly associated with human traits and diseases, yet few have been causally identified. We developed the Massively Parallel Reporter Assay for 3’UTRs (MPRAu) to sensitively assay 12,173 3’UTR variants. We applied MPRAu to six human cell lines, focusing on genetic variants associated with genome-wide association studies (GWAS) and human evolutionary adaptation. MPRAu e...

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Literature Corpus work: 85203554-5c28-5599-98ad-aed83a6c5481
DOI: 10.1101/2021.01.13.424697

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