Article

A systematic delineation of 3′UTR regulatory elements and their contextual associations

2025-06-09

Abstract excerpt

<h4>SUMMARY</h4> The 3′UTR encodes regulatory information that shapes transcript abundance and subcellular distribution, yet the underlying sequence rules remain incompletely defined. Using SEERS, we quantified the effects of ∼2 million synthetic 3′UTR inserts in A549 and HCT116 cells on RNA output and nuclear-cytoplasmic partitioning. We identify a broad repertoire of short (2∼8 nt) elements whose effects largel...

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Literature Corpus work: 1dbbb466-0034-5a66-a988-f8a6525332c1
DOI: 10.1101/2025.06.09.658412

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