Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution.

Cell - 30 Sept 2021

Griesemer Dustin, Xue James R, Reilly Steven K, Ulirsch Jacob C, Kukreja Kalki, Davis Joe R, Kanai Masahiro, Yang David K, Butts John C, Guney Mehmet H, Luban Jeremy, Montgomery Stephen B, Finucane Hilary K, Novina Carl D, Tewhey Ryan, Sabeti Pardis C

Abstract excerpt

3' untranslated region (3'UTR) variants are strongly associated with human traits and diseases, yet few have been causally identified. We developed the massively parallel reporter assay for 3'UTRs (MPRAu) to sensitively assay 12,173 3'UTR variants. We applied MPRAu to six human cell lines, focusing on genetic variants associated with genome-wide association studies (GWAS) and human evolutionary adaptation. MPRAu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Algorithms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Evolution

Share to Disease

Share to Genes, Reporter

Share to Polyribosomes

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 34534445
DOI: 10.1016/j.cell.2021.08.025
PMCID: PMC8487971

Genes

LEPR
PILRB
TRIM14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution.PMID 34534445Read ↗

Genome-wide functional screen of 3’UTR variants uncovers causal variants for human disease and evolutionSemantic proximity Read ↗

Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA StabilitySemantic proximity Read ↗

The role of untranslated region variants in Mendelian disease: a review.Semantic proximity Read ↗

utR.annotation: a tool for annotating genomic variants that could influence post-transcriptional regulationSemantic proximity Read ↗

Genome-wide detection of human 5' UTR variants that impact protein translation.Semantic proximity Read ↗

Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3' untranslated region mutations.Semantic proximity Read ↗

The length of the expressed 3’ UTR is an intermediate molecular phenotype linking genetic variants to complex diseasesSemantic proximity Read ↗

Predicting functional UTR variants by integrating region-specific features.Semantic proximity Read ↗

Regulatory features aid interpretation of 3’UTR VariantsSemantic proximity Read ↗

A systematic delineation of 3′UTR regulatory elements and their contextual associationsSemantic proximity Read ↗

Systematic identification of functional SNPs interrupting 3'UTR polyadenylation signals.Semantic proximity Read ↗

An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.