Article

A Mammalian Genomic Signature Shaped by Single Nucleotide Variants Regulates Transcriptome Integrity and Diversity

2025-09-12

Abstract excerpt

<h4>Background</h4> Many functional features of mammalian genomic sequences remain poorly defined, especially how sequence motifs and genetic variants within non-coding regions (NCRs) regulate transcriptome integrity and diversity. We have shown that G-tracts unusually positioned between the polypyrimidine tract and 3′ AG repress usage of the AG and are enriched at cryptic splice sites in cancer cells but their b...

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Literature Corpus work: 63fe74f0-eb99-5f84-a638-a5b410c9251f
DOI: 10.1101/2025.09.11.675687

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