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Article

Causal Association Between mTOR-Dependent Protein Levels and Alzheimer's Disease: A Mendelian Randomization Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Cai Hong-Yan, Hou Si-Jia, Wen Rui, Feng Qi-Fan, Xi Yu-Jia, Zhang Sheng-Xiao, Qiao Jun, Wu Mei-Na

Abstract excerpt

BACKGROUND: Most previous studies supported that the mammalian target of rapamycin (mTOR) is over-activated in Alzheimer's disease (AD) and exacerbates the development of AD. It is unclear whether the causal associations between the mTOR signaling-related protein and the risk for AD exist. OBJECTIVE: This study aims to investigate the causal effects of the mTOR signaling targets on AD. METHODS: We explored...

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Source

Identifiers

PMID: 37393500
DOI: 10.3233/JAD-230128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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