Mapping the genetically predicted associations of plasma metabolites with sarcopenia and aging traits: Evidence from bidirectional Mendelian randomization and transcriptome analysis.

Abstract excerpt

Observational studies have demonstrated associations between plasma metabolites and sarcopenia/aging. This study aimed to investigate the genetically predicted associations between plasma metabolites and sarcopenia/aging traits and to discover the regulating genes. A Mendelian randomization (MR) study was performed using metabolomic data obtained from the Canadian Longitudinal Study on Aging cohort. Data of...

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