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Article

Genetic Evidence Supporting a Causal Association Between mTOR-Dependent EIF-4E Circulating Protein Level and Osteoporosis.

Advances in therapy - 1 Nov 2023

Cheng Ting, Zhang Yao-Chen, Fan Ke-Yi, Hu Jing-Xi, Wang Qian, Wang Qi, Liu Liu, Zhang He-Yi, Hou Yao-Pu, Li Xiao-Feng, Zhang Sheng-Xiao

Abstract excerpt

INTRODUCTION: The mechanistic target of rapamycin (mTOR) regulates bone homeostasis, a crucial factor in osteoporosis (OP) development. However, most research is based on observational studies, and the causality remains uncertain. Therefore, we analyzed two samples of mendelian randomization (MR) to determine whether there is a causal relationship between mTOR-dependent circulating proteins and OP. METHODS:...

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PMID: 37728694
DOI: 10.1007/s12325-023-02676-x

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