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Comprehensive analysis of the effect of rs2295080 and rs2536 polymorphisms within the mTOR gene on cancer risk.

Bioscience reports - 31 Jul 2020

Qi Guang-Hui, Wang Chun-Hui, Zhang Hong-Ge, Yu Jian-Guo, Ding Fei, Song Zhi-Chao, Xia Qing-Hua

Abstract excerpt

There is still no conclusion on the potential effect of the rs2295080 and rs2536 polymorphisms of mTOR (mammalian target of rapamycin) gene on different cancers. Herein, we performed a comprehensive assessment using pooled analysis, FPRP (false-positive report probability), TSA (trial sequential analysis), and eQTL (expression quantitative trait loci) analysis. Eighteen high-quality articles from China were...

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Identifiers

PMID: 32597485
DOI: 10.1042/BSR20191825
PMCID: PMC7350887

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