Article

β-Amyloid as a new target to suppress tonic PTH hypersecretion in primary hyperparathyroidism

2025-05-28

Abstract excerpt

Primary hyperparathyroidism (PHPT) is a common endocrine disorder of aging closely linked to vitamin D deficiency. Reduced vitamin D receptor activities promote parathyroid hormone (PTH) hypersecretion by increasing the heterodimerization of the type B γ-aminobutyric acid receptor 1 (GABA B1 R) with the extracellular Ca 2+ -sensing receptor (CaSR) in parathyroid cells; however, endogenous activators of the heterod...

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Literature Corpus work: e244b777-2c6f-520c-bafa-0b3c1177933c
DOI: 10.1101/2025.05.27.25328314

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