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Article

Calcium ionophore increases amyloid beta peptide production by cultured cells.

Biochemistry - 19 Apr 1994

Querfurth H W, Selkoe D J

Abstract excerpt

Amyloid beta peptide (A beta) is released into the media of a variety of cells in culture during normal metabolism. The discovery of several missense mutations within or flanking the A beta region of the beta amyloid precursor protein (beta APP) in familial Alzheimer's disease provides strong evidence for a role of altered processing of beta APP in the pathogenesis of this disorder. The cellular mechanisms that...

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Source

Identifiers

PMID: 8161510
DOI: 10.1021/bi00181a016

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calcium ionophore increases amyloid beta peptide production by cultured cells.PMID 8161510Read ↗

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