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Article

Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2013

Xia Wen-Fang, Jung Ji-Ung, Shun Cui, Xiong Shan, Xiong Lei, Shi Xing-Ming, Mei Lin, Xiong Wen-Cheng

Abstract excerpt

Reduced bone mineral density and hip fracture are frequently observed in patients with Alzheimer's disease (AD). However, mechanisms underlying their association remain poorly understood. Amyloid precursor protein (APP) is a transmembrane protein that is ubiquitously expressed in bone marrow stromal cells (BMSCs), osteoblasts (OBs), macrophages (BMMs), and osteoclasts (OCs). Mutations in the APP gene identified...

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Identifiers

PMID: 23649480
DOI: 10.1002/jbmr.1954
PMCID: PMC7104794

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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