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Article

Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein.

Journal of neurochemistry - 1 Aug 2015

Cuddy Leah K, Seah Claudia, Pasternak Stephen H, Rylett Rebecca Jane

Abstract excerpt

The high-affinity choline transporter (CHT) is responsible for choline uptake into cholinergic neurons, with this being the rate-limiting step for acetylcholine production. Altering CHT protein disposition directly impacts choline uptake activity and cholinergic neurotransmission. Amyloid precursor protein (APP) interacts with CHT proteins and increases their endocytosis from the cell surface. The goal of this...

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Identifiers

PMID: 25970623
DOI: 10.1111/jnc.13167

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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