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Article

Tuberoinfundibular peptide 39 binds to the parathyroid hormone (PTH)/PTH-related peptide receptor, but functions as an antagonist.

Endocrinology - 1 Feb 2001

Jonsson K B, John M R, Gensure R C, Gardella T J, Jüppner H

Abstract excerpt

The tuberoinfundibular peptide TIP39 [TIP-(1-39)], which exhibits only limited amino acid sequence homology with PTH and PTH-related peptide (PTHrP), stimulates cAMP accumulation in cells expressing the PTH2 receptor (PTH2R), but it is inactive at the PTH/PTHrP receptor (PTH1R). However, when using either (125)I-labeled rat [Nle(8,21),Tyr(34)]PTH-(1-34)amide (rPTH) or (125)I-labeled human...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11159842
DOI: 10.1210/endo.142.2.7945

Genes

PTH
PTH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tuberoinfundibular peptide 39 binds to the parathyroid hormone (PTH)/PTH-related peptide receptor, but functions as an antagonist.PMID 11159842Read ↗

Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.Semantic proximity Read ↗

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.Semantic proximity Read ↗

Development of a rat parathyroid hormone 2 receptor antagonist.Semantic proximity Read ↗

Identification and Characterization of the Zebrafish and Fugu Genes Encoding Tuberoinfundibular Peptide 39Semantic proximity Read ↗

The Parathyroid Hormone 2 (PTH2) ReceptorSemantic proximity Read ↗

Phosphorylation of the receptor for PTH and PTHrP is required for internalization and regulates receptor signaling.Semantic proximity Read ↗

Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations.Semantic proximity Read ↗

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2Semantic proximity Read ↗

Differences in binding affinities of human PTH(1-84) do not alter biological potency: a comparison between chemically synthesized hormone, natural and mutant forms.Semantic proximity Read ↗

Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).Semantic proximity Read ↗

Identification and Characterization of Two Parathyroid Hormone-Like Molecules in ZebrafishSemantic proximity Read ↗

Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.Semantic proximity Read ↗

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