Article

Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis

2024-08-16

Abstract excerpt

<h4>SUMMARY</h4> The accumulation of amyloid fibrils has been identified in tissues outside the brain, yet little is understood about the formation of extracerebral amyloidosis and its impact on the aging process of these organs. Here, we demonstrate that both transgenic mice modeling Alzheimer’s disease (AD) and naturally aging mice exhibit accumulated senescent bone marrow adipocytes (BMAds), accompanied by amy...

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Literature Corpus work: 17b33ea2-fc2a-5e21-b3bf-73a8d23b6e0a
DOI: 10.1101/2024.08.15.608092

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