Article

A Bacterial Bile Acid Metabolite Modulates T <sub>reg</sub> Activity through the Nuclear Hormone Receptor NR4A1

2021-01-09

Abstract excerpt

<h4>SUMMARY</h4> Bile acids act as signaling molecules that regulate immune homeostasis, including the differentiation of CD4 + T cells into distinct T cell subsets. The bile acid metabolite isoallolithocholic acid (isoalloLCA) enhances the differentiation of anti-inflammatory regulatory T cells (Treg cells) by facilitating the formation of a permissive chromatin structure in the promoter region of the transcrip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1f70e57-d65d-5595-886d-bfc4b9ceeb00
DOI: 10.1101/2021.01.08.425963

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Bacterial Bile Acid Metabolite Modulates T <sub>reg</sub> Activity through the Nuclear Hormone Receptor NR4A1DOI 10.1101/2021.01.08.425963Read

Human gut bacteria produce T <sub>H</sub> 17-modulating bile acid metabolitesSemantic proximity Read

A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel diseaseSemantic proximity Read

HDAC6/FOXP3/HNF4α axis promotes bile acids induced gastric intestinal metaplasiaSemantic proximity Read

Individual intestinal symbionts induce a distinct population of RORγ <sup>+</sup> regulatory T cellsSemantic proximity Read

Understanding the Physiological Functions of the Host Xenobiotic-sensing Nuclear Receptors PXR and CAR on the Gut Microbiome using Genetically Modified MiceSemantic proximity Read

24-Nor-ursodeoxycholic acid counteracts T <sub>H</sub> 17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating T <sub>H</sub> 17 cellsSemantic proximity Read

Tong-Xie-Yao-Fang strengthens intestinal feedback control of bile acid synthesis to ameliorate irritable bowel syndrome by enhancing bile salt hydrolase-expressing microbiotaSemantic proximity Read

Commensal bacterial-derived retinoic acid primes host defense to intestinal infectionSemantic proximity Read

Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in OncogenesisSemantic proximity Read

Pregnane X Receptor as the “Sensor and Effector” in Regulating EpigenomeSemantic proximity Read

Hnf4a mediates microbial control of intestinal gene expression and inflammationSemantic proximity Read

Crosstalk Between Bile Acids and Intestinal Epithelium: Multidimensional Roles of Farnesoid X Receptor and Takeda G Protein Receptor 5Semantic proximity Read