Article

Hnf4a mediates microbial control of intestinal gene expression and inflammation

2016-12-28

Abstract excerpt

<h4>ABSTRACT</h4> Microbiota influence diverse aspects of intestinal epithelial physiology and disease in part by controlling tissue-specific transcription of host genes. However, host genomic mechanisms mediating microbial control of host gene expression are poorly understood. Using an unbiased screening strategy, we found that the zebrafish Hepatic nuclear factor 4 alpha (Hnf4a) transcription factor specificall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b7d32b6-348f-551e-ac03-70e600dfe077
DOI: 10.1101/097055

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hnf4a mediates microbial control of intestinal gene expression and inflammationDOI 10.1101/097055Read

Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.Semantic proximity Read

Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestineSemantic proximity Read

Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal AdenocarcinomasSemantic proximity Read

Gut Microbiota Has a Widespread and Modifiable Effect on Host Gene RegulationSemantic proximity Read

NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitisSemantic proximity Read

Combined suppression of HNF4α and HNF4γ Drives a Reversible Epithelial-Intrinsic Barrier Defect in Crohn’s DiseaseSemantic proximity Read

Functional screen of Inflammatory bowel disease genes reveals key epithelial functionsSemantic proximity Read

An integrated gene catalog of the zebrafish gut microbiome reveals significant homology with mammalian microbiomesSemantic proximity Read

Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterationsSemantic proximity Read

Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling moleculesSemantic proximity Read

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networksSemantic proximity Read

Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel diseaseSemantic proximity Read