Article

Understanding the Physiological Functions of the Host Xenobiotic-sensing Nuclear Receptors PXR and CAR on the Gut Microbiome using Genetically Modified Mice

2020-06-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Pharmacological activation of the host xenobiotic-sensing nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding the physiological functions of PXR and CAR on the gut microbiome, which is an important regulator for the host immune surveill...

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Literature Corpus work: 8ed4e2b7-8a93-58b3-ac1a-fc259c81f61d
DOI: 10.21203/rs.3.rs-36593/v1

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