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Article

Pregnane X Receptor as the “Sensor and Effector” in Regulating Epigenome

7 Oct 2014

Abstract excerpt

The pregnane X receptor (PXR, NR1I2) is a ligand-activated nuclear receptor which plays an essential role in organism's metabolic detoxification system by sensing the presence of xenobiotics and triggering detoxification responses. In addition to its role in xenobiotic metabolism, PXR has pleiotropic functions in regulating immune/inflammatory responses, cell proliferation, bile acid/cholesterol metabolism,...

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PMID: 25294580
DOI: 10.1002/jcp.24838

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