Article

Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis

2023-10-02

Abstract excerpt

<h4>Summary</h4> The leukemia inhibitory factor (LIF) is member of IL-6 family of cytokines involved immune regulation, morphogenesis and oncogenesis. In cancer tissues, LIF binds a heterodimeric receptor (LIFR), formed by a LIFRβ subunit and glycoprotein(gp)130, promoting epithelial mesenchymal transition and cell growth. Bile acids are cholesterol metabolites generated at the interface of host metabolism and th...

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Literature Corpus work: 468ee3b9-373f-52b2-8a97-3d1bd37eb9bc
DOI: 10.1101/2023.09.30.560269

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