Article

Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells

2019-11-23

Abstract excerpt

Human pluripotent stem cells (PSC) often acquire genetic changes on prolonged culture, which pose concerns for their use in research and regenerative medicine (Amps et al., 2011, Seth et al., 2011). The acquisition of these changes during culture necessarily first requires mutation and then selection of those mutations that provide a growth advantage. Whilst selection accounts for the recurrent nature of the varia...

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Literature Corpus work: e1d5e697-327b-5c8a-8947-d9146b1ef5b8
DOI: 10.1101/853234

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