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iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?

28 Feb 2019

Abstract excerpt

The use of induced Pluripotent Stem Cells (iPSC) as a source of autologous tissues shows great promise in regenerative medicine. Nevertheless, several major challenges remain to be addressed before iPSC-derived cells can be used in therapy, and experience of their clinical use is extremely limited. In this review, the factors affecting the safe translation of iPSC to the clinic are considered, together with an...

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PMID: 30823421
DOI: 10.3390/jcm8030288

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