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The macrophage reprogramming ability of antifolates reveals soluble CD14 as a potential biomarker for methotrexate response in rheumatoid arthritis

2021-05-11

Abstract excerpt

<h4>ABSTRACT</h4> The physio-pathological relevance of the one-carbon metabolism (OCM) is illustrated by the chemotherapeutic and anti-inflammatory effects of the antifolates Pemetrexed (PMX) and Methotrexate (MTX) in cancer and rheumatoid arthritis (RA). We report that OCM determines the functional and gene expression profile of human macrophages. PMX induces the acquisition of a p53-dependent proinflammatory ge...

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Literature Corpus work
e18d711c-fc72-518a-8938-f060effb35e7
DOI
10.1101/2021.05.11.443581
Open publication

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The macrophage reprogramming ability of antifolates reveals soluble CD14 as a potential biomarker for methotrexate response in rheumatoid arthritisDOI 10.1101/2021.05.11.443581
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